Comparing the Intestinotrophic Effects of 2 Glucagon-Like Peptide-2 Analogues in the Treatment of Short-Bowel Syndrome in Neonatal Piglets.
Mirielle L PaulinePatrick N NationPamela R WizzardTierah HinchliffeTong WuVioletta DimitriadouJustine M TurnerPaul W WalesPublished in: JPEN. Journal of parenteral and enteral nutrition (2020)
APRA injected only twice during the 7 consecutive days demonstrated a superior intestinotrophic effect compared with TED injected once daily. Even at more comparable drug exposure, when TED was injected twice a day, APRA showed superior trophic activity at the mucosal level. This is highly relevant for the treatment of pediatric SBS, given the markedly lower dose frequency by subcutaneous injection of APRA.