IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.
Ya GaoMaurice de WitEduard A StruysHerma C Z van der LindeGajja S SalomonsMartine L M LamfersRob WillemsenPeter A E Sillevis SmittPim J FrenchPublished in: PloS one (2018)
We have generated a transgenic zebrafish model system for mutations in IDH1 that can be used for functional analysis and drug screening. Our model systems help understand the biology of IDH1 mutations and its role in tumor formation.