Ru(II)-Catalyzed C-H Activation and Annulation Reaction via Carbon-Carbon Triple Bond Cleavage.

Rashmi PrakashBidisha R BoraRomesh C BoruahSanjib Gogoi

Published in: Organic letters (2018)

An unprecedented Ru(II)-catalyzed C-H activation and annulation reaction, which proceeds via C-C triple bond cleavage, is reported. This reaction of 2-phenyldihydrophthalazinediones with alkynes, which works most efficiently in the presence of bidented ligand 1,3-bis(diphenylphosphino)propane, affords good yields of substituted quinazolines.

Keyphrases

electron transfer
room temperature
dna binding
energy transfer
molecular docking
molecular dynamics simulations