A novel approach to determine two optimal cut-points of a continuous predictor with a U-shaped relationship to hazard ratio in survival data: simulation and application.

Yimin ChenJialing HuangXianying HeYongxiang GaoGehendra MaharaZhuochen LinJin-Xin Zhang

Published in: BMC medical research methodology (2019)

In general, the optimal equal-HR method is recommended to discretize a continuous predictor with right-censored outcomes if the predictor has an asymmetric U-shaped relationship with log relative hazards based on Cox regression models.

Keyphrases

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insulin resistance
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