Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway.

Baozhu DingSongyan GengXiaojie HouXuelian MaHuazhou XuFan YangKun LiuXuelian Ma Guoping Ma

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

DN golden hamster kidney NLRP3-Caspase-1-GSDMD signalling was enhanced. BBR can reduce oxidative stress damage by regulating antioxidative Nrf2 and then regulating NLRP3-Caspase-1-GSDMD signalling to inhibit pyroptosis, antagonizing DN inflammation-induced damage.

Keyphrases

oxidative stress
induced apoptosis
nlrp inflammasome
diabetic rats
diabetic nephropathy
cell death
ischemia reperfusion injury
dna damage
single cell
cell therapy
endoplasmic reticulum stress
signaling pathway
mesenchymal stem cells
drug induced
heat shock