IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis.

Pei-Yi ChuWei-Chieh HuangShiao-Lin TungChung-Ying TsaiChih Jung ChenYu-Chin LiuChia-Wen LeeYang-Hsiang LinHung-Yu LinCheng-Yi ChenChau-Ting YehKwang-Huei LinHsiang-Cheng Chi

Published in: Cell & bioscience (2022)

In summary, our present study unveiled a novel regulatory mechanism for c-MYC-driven oncogenesis underlined by IFITM3-mediated signaling crosstalk between MET associated AKT signaling cascade.

Keyphrases

signaling pathway
cell proliferation
transcription factor
tyrosine kinase
stem cells
papillary thyroid
epithelial mesenchymal transition
pi k akt
squamous cell carcinoma
young adults
lymph node metastasis