Homoharringtonine sensitizes pancreatic cancer to erlotinib by direct targeting and miRNA-130b-3p-mediated EphB4-JAK2-STAT3 axis.

Ammar SarwarZeren ZhuMan ZhuXiaoyu TangQi SuTianfeng YangWenjun TangYanmin Zhang

Published in: The Journal of pharmacy and pharmacology (2023)

HHT demonstrates potential anticancer activities in PC by downregulating EphB4/JAK2/STAT3 signalling. HHT also produces synergistic effects with erlotinib.

Keyphrases

advanced non small cell lung cancer
epidermal growth factor receptor
cancer therapy
tyrosine kinase
human health
oxidative stress
risk assessment
endoplasmic reticulum stress