Sesquiterpenoid Compounds from Curcuma kwangsiensis.
Hai-Bing LiaoWu-Ying FengHeng-Shan WangDong LiangPublished in: Chemistry & biodiversity (2019)
Two previously undescribed guaiane-type sesquiterpenes (1 and 2), a pair of new salvialane-type sesquiterpenes (3a and 3b), together with 11 known compounds were isolated and purified from the rhizomes of Curcuma kwangsiensis. Their structures were elucidated by the extensive spectroscopic data (1D- and 2D-NMR) analysis. All the isolated compounds were assessed for their anti-neuroinflammatory activity by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine BV-2 microglial cells in vitro assay, and the isolates 3 and 11 showed anti-neuroinflammatory activity with IC50 values of 1.85 and 20.05 μm, respectively.
Keyphrases
- inflammatory response
- lps induced
- nitric oxide
- lipopolysaccharide induced
- induced apoptosis
- high resolution
- magnetic resonance
- signaling pathway
- molecular docking
- toll like receptor
- high throughput
- big data
- neuropathic pain
- hydrogen peroxide
- oxidative stress
- nitric oxide synthase
- machine learning
- endoplasmic reticulum stress
- data analysis
- cell proliferation
- immune response
- solid state
- single cell