High-throughput nucleotide sequencing for bacteriome studies in oral squamous cell carcinoma: a systematic review.
Ruth Tramontani RamosCamila Stofella SodréPaulo Matheus Guerra Ribeiro de Sousa RodriguesAlexandre Marques Paes da SilvaMilenna Silva FulyHenrique Fragoso Dos SantosLucio Souza GonçalvesDennis de Carvalho FerreiraMarcia Gonçalves RibeiroPublished in: Oral and maxillofacial surgery (2020)
In summary, the results corroborated dysbiosis in OSCC patients, with enrichment of microbial taxa that are associated with inflammation and production of acetaldehyde. However, variations of study design and sample size were observed among the studies, as well as a shortage of more detailed analyses of possible correlations between risk habits and OSCC. This lack of more detailed analysis may be the cause of the inconsistencies in regard of the alterations reported for certain genera and species. In conclusion, there is an association between OSCC and oral microbiota dysbiosis, but its role in oral carcinogenesis needs to be clarified in more detail.