Synthesis, molecular docking, ADMET, and evaluation of the anxiolytic effect in adult zebrafish of synthetic chalcone (E)-3-(4-(dimethylamino)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one: An in vivo and in silico approach.
Larissa Santos OliveiraMaria Kueirislene Amâncio FerreiraFrancisco Wagner de Queiroz Almeida-NetoAntonio Wlisses da SilvaJosé Ivo Lima Pinto FilhoMatheus Nunes da RochaEmanuelle Machado MarinhoWalber Henrique Ferreira RibeiroMárcia Machado MarinhoEmmanuel Silva MarinhoJane Eire Silva Alencar de MenezesHélcio Silva Dos SantosPublished in: Fundamental & clinical pharmacology (2023)
Thus, this study adds new evidence and highlights that chalcone can potentially be used to develop compounds with anxiolytic properties.