The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis.
Dimitrios ChanouzasMichael SagmeisterLovesh DyallPhoebe SharpLucy PowleySerena JohalJessica BowenPeter NightingaleCharles J FerroMatthew D MorganPaul MossLorraine HarperPublished in: Arthritis research & therapy (2018)
The host cellular immune response to CMV leads to the expansion of cytotoxic CD4+CD28null T cells that express endothelial homing markers and are independently linked to increased arterial stiffness, a marker of cardiovascular mortality. Suppression of CMV in AAV may be of therapeutic value in reducing the risk of cardiovascular disease.