Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda.
Betty BalikagalaMiki Sakurai-YatsushiroShin-Ichiro TachibanaMie IkedaMasato YamauchiOsbert T KaturoEdward H NtegeMakoto SekiharaNaoyuki FukudaNobuyuki TakahashiShouki YatsushiroToshiyuki MoriMakoto HiraiWalter OpioPaul S ObwoyaDenis A AnywarMary A AumaNirianne M Q PalacpacTakafumi TsuboiEmmanuel I Odongo-AginyaEisaku KimuraMartin OgwangToshihiro HoriiToshihiro MitaPublished in: Malaria journal (2020)
This study found evidence of stable persistence of chloroquine susceptibility with the fixation of pfcrt K76 in Northern Uganda after discontinuation of chloroquine in the region. Accumulation of similar evidence in other endemic areas in Uganda could open channels for possible future re-use of chloroquine as an option for malaria treatment or prevention.