Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia.

Rafael Short FerreiraPaulo Roberto RibeiroJuliana Helena Castro E SilvaJuliana Bender HoppeMonique Marylin Alves de AlmeidaBeatriz Correia de Lima FerreiraGustavo Borges AndradeSuzana Braga de SouzaLuzimar Gonzaga FerdandezMaria de Fátima Dias CostaChristianne Gazzana SalbegoAndrea Domenico RiveraAline LongoniAdriano Martimbianco de AssisFrancesca PieropanJosé Cláudio Fonseca MoreiraSilvia Lima Costa Arthur Morgan Butt Victor Diógenes Amaral Silva

Published in: BMC complementary medicine and therapies (2023)

This study provides evidence that EDAC is cytoprotective against ischemia and glutamate excitotoxicity by modulating astrocyte responses and stimulating their glutamate homeostatic mechanisms.

Keyphrases

oxidative stress
cerebral ischemia
signaling pathway
resting state
white matter
functional connectivity
anti inflammatory
multiple sclerosis
subarachnoid hemorrhage