A photosensitizer with conformational restriction for enhanced photodynamic therapy.

Haiqiao HuangSaran LongDaipeng HuangJianjun Du Jiangli Fan Xiaojun Peng

Published in: Chemical communications (Cambridge, England) (2021)

A rigid hemicyanine CSZ-J and a flexible molecule ESZ-J were synthesized. In particular, the conformationally restrained CSZ-J had higher fluorescence quantum yields, longer fluorescence lifetimes and higher triplet state quantum yields. CSZ-J could generate highly cytotoxic ROS simultaneously via type I and type II processes. This will contribute to the design and development of new photosensitizers in the future.

Keyphrases

photodynamic therapy
energy transfer
molecular dynamics
single molecule
fluorescence imaging
quantum dots
dna damage
cell death
molecular dynamics simulations
current status
reactive oxygen species
monte carlo