Comparative Effectiveness and Safety of Direct Oral Anticoagulants in Low Body Weight Patients with Atrial Fibrillation: A Systematic Review and Meta-analysis.
Mohamed Nabil ElshafeiMuhammad SalemAhmed El-BardissyMohamed S AbdelmoneimAhmed KhalilSherine ElhadadMutasem Al MistarihiMohammed DanjumaPublished in: Cardiovascular drugs and therapy (2024)
) with atrial fibrillation was associated with increased risks of stroke-related events, composite outcomes, and mortality compared to non-low body weight cohorts patients. At the same time, there was no significant difference in terms of major bleeding events. This finding has provided the first resolution of pervading uncertainty surrounding the use of DOAC analogs in these patient cohorts and suggests the need for follow-up confirmatory systematic studies in this group of patients.
Keyphrases
- body weight
- direct oral anticoagulants
- atrial fibrillation
- venous thromboembolism
- end stage renal disease
- left atrial
- catheter ablation
- oral anticoagulants
- left atrial appendage
- heart failure
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- percutaneous coronary intervention
- prognostic factors
- case report
- risk factors
- risk assessment
- molecular docking
- skeletal muscle
- human health
- single molecule
- left ventricular
- patient reported outcomes
- brain injury
- adipose tissue
- molecular dynamics simulations
- acute coronary syndrome
- weight loss
- insulin resistance
- metabolic syndrome
- cerebral ischemia