Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade.
Giuseppe Lo RussoMassimo MoroMichele SommarivaValeria CancilaMattia BoeriGiovanni CentonzeSimona FerroMonica GanzinelliPatrizia GaspariniVeronica HuberMassimo MilioneLuca PorcuClaudia ProtoGiancarlo PruneriDiego SignorelliSabina SangalettiLucia SfondriniChiara StortiElena TassiAlberto BardelliSilvia MarsoniValter TorriClaudio TripodoMario Paolo ColomboAndrea AnichiniLicia RivoltiniAndrea BalsariGabriella SozziMarina Chiara GarassinoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
These results suggest a crucial role of TAM reprogramming, upon Fc receptor engagement by ICI, eventually inducing HP and provide clues on a distinctive immunophenotype potentially able to predict HP.See related commentary by Knorr and Ravetch, p. 904.
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