Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice.

Shunsuke UeharaHideyuki MukaiTeruhito YamashitaMasanori KoideKohei MurakamiNobuyuki UdagawaYasuhiro Kobayashi

Published in: Journal of bone and mineral metabolism (2022)

Our results showed that Pkn3 has potential as a therapeutic target for bone loss due to increased bone resorption. SB202190 is promising as a lead compound for the development of novel anti-bone-resorbing agents.

Keyphrases

bone loss
protein kinase
signaling pathway
bone mineral density
type diabetes
metabolic syndrome
body mass index
body composition
insulin resistance