Type I Diabetes Delays Perfusion and Engraftment of 3D Constructs by Impinging on Angiogenesis; Which can be Rescued by Hepatocyte Growth Factor Supplementation.
Sara S NunesRupal HatkarJames B HoyingYasaman AghazadehSara S NunesPublished in: Cellular and molecular bioengineering (2019)
We show for the first time that diabetes affects HGF secretion in microvessels, which in turn prevents the engraftment of engineered tissues. Exogenous supplementation of HGF, restores angiogenic growth in 3D constructs showing promise for application in cell-based regenerative therapies.
Keyphrases
- growth factor
- type diabetes
- cell therapy
- cardiovascular disease
- glycemic control
- stem cells
- single cell
- mesenchymal stem cells
- gene expression
- hematopoietic stem cell
- endothelial cells
- living cells
- magnetic resonance imaging
- fluorescent probe
- contrast enhanced
- computed tomography
- skeletal muscle
- wound healing
- tissue engineering
- metabolic syndrome