1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression.
Luiz Henrique Gomes MatheusStephanie Vanin DalmazzoRodrigo Barbosa Oliveira BritoLucas Alves PereiraRobson José de AlmeidaCleber Pinto CamachoHumberto DellêPublished in: BMC cancer (2020)
In conclusion, it is rational to inhibit IDO1 in BC, among other factors because it contributes to AHR activation. However, MT needs to be carefully evaluated for BC because it is an AHR pathway agonist independently of its effects on IDO1.
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