Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases.

Jie DuZujia ChenXiaodong ChenJiahui ZhangYaojun WangTingting ZhaoDalong WangChangyuan WangYanwei ChenQiang MengHuijun SunKexin LiuJingjing Wu

Published in: Current drug metabolism (2024)

GP exhibits a significant inhibitory effect on CYP46A1 activity in vitro and in vivo, and the protein expressions of CYP46A1, HMGCR, and NMDAR are also inhibited by GP, which are of considerable clinical significance for GP's potential therapeutic role in treating neurological diseases.

Keyphrases

endothelial cells
cerebral ischemia
protein protein
amino acid
water soluble