Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
Anastasia ProkopiChristoph H TrippBart TummersFlorian HornsteinerSarah SpoeckJeremy Chase CrawfordDerek R ClementsMirjana EfremovaKatharina HutterLydia BellmannGiuseppe CappellanoBruno L CadilhaSebastian KoboldLouis BoonDaniela OrtnerZlatko TrajanoskiSuzie ChenTanja D de GruijlJuliana IdoyagaDouglas R GreenPatrizia StoitznerPublished in: Journal for immunotherapy of cancer (2021)
Our results set forth the importance of skin DC in cancer immunotherapy, and demonstrates that restoring DC function is key to enhancing tumor immunogenicity and subsequently responsiveness to checkpoint blockade therapy.