Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats.
Jian-Ru LiHang-Zhe XuSheng NieYu-Cong PengLin-Feng FanZhi-Jiang WangCheng WuFeng YanJing-Yin ChenChi GuChun WangJing-Sen ChenLin WangChen GaoPublished in: Journal of neuroinflammation (2017)
Together, our present study indicated that NLRP3 inflammasome and caspase-1 activation play a deleterious role in early brain injury and fluoxetine mitigates NLRP3 inflammasome and caspase-1 activation through autophagy activation after SAH, providing a potential therapeutic agent for SAH treatment.