Modelling the variable incorporation of aromatic amino acids in the tyrocidines and analogous cyclodecapeptides.
J Arnold VoslooJacky L SnoepMarina RautenbachPublished in: Journal of applied microbiology (2019)
Subtly exploiting the inherent promiscuity of the nontemplate coded peptide synthesis allows for external control of peptide identity, without using genetic manipulation. Such versatility is exploitable in the production of targeted peptide complexes and rare peptides where production processes are reliant on nonribosomal synthesis.