Upfront primary tumor resection versus upfront systemic therapy for metastatic colorectal cancer: a systematic review and meta-analysis.
Shih-Jung LoShu-Huan HuangI-Li LaiYih-Jong ChernYu-Jen HsuChun-Kai LiaoChing-Chung ChengWen-Sy TsaiPao-Shiu HsiehJeng-Fu YouPublished in: International journal of colorectal disease (2023)
In RCTs, upfront PTR for mCRC did not improve OS and enhanced the risk of 60-day mortality. However, upfront PTR seemed to increase OS in RCSs with PSM or IPTW. Therefore, whether upfront PTR should be used for mCRC remains unclear. Further large RCTs are required.