Photo-tethered molecular beacons for superior light-induction.

Robin KlimekMantian WangVivien R McKenneyErin M SchumanAlexander Heckel

Published in: Chemical communications (Cambridge, England) (2021)

We developed a superior class of light-activatable molecular beacons with photo-tethered loop regions. Two simple modifications and probe cyclisation prevent the molecular beacon from hybridising with the target RNA before light-activation. Full activity of the molecular beacon is elicited upon illumination with 365 nm light.

Keyphrases

single molecule
photodynamic therapy
transcription factor
quantum dots