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Wide-field intensity fluctuation imaging.

Qingwei FangAlankrit TomarAndrew K Dunn
Published in: Biomedical optics express (2024)
The temporal intensity fluctuations contain important information about the light source and light-medium interaction and are typically characterized by the intensity autocorrelation function, g 2 ( τ ). The measurement of g 2 ( τ ) is a central topic in many optical sensing applications, ranging from stellar intensity interferometer in astrophysics, to fluorescence correlation spectroscopy in biomedical sciences and blood flow measurement with dynamic light scattering. Currently, g 2 ( τ ) at a single point is readily accessible through high-frequency sampling of the intensity signal. However, two-dimensional wide-field imaging of g 2 ( τ ) is still limited by the cameras' frame rate. We propose and demonstrate a 2-pulse within-exposure modulation approach to break through the camera frame rate limit and obtain the quasi g 2 ( τ ) map in wide field with cameras of only ordinary frame rates.
Keyphrases
  • high frequency
  • high intensity
  • high resolution
  • blood flow
  • transcranial magnetic stimulation
  • single molecule
  • healthcare
  • high speed
  • mass spectrometry