Exosomal MATN3 of Urine-Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF-β.

Zhu Guo WeiLiang Su RongYao Zhou GuoQing Zhang Shuai Yang Xiaolin Wu ChenSheng Qiu WenBin Cong Nana Shen JianWei Guo Chang Liu Shang-You Yang Dong-Ming Xing Yan Wang Bo-Hua Chen HongFei Xiang

Published in: Oxidative medicine and cellular longevity (2021)

Our study suggests that reduced MATN3 can be considered a characteristic of intervertebral disc degeneration. USC-exos may represent a potentially effective agent for alleviating intervertebral disc degeneration by promoting NPC proliferation and ECM synthesis by transferring the MATN3 protein.

Keyphrases

stem cells
signaling pathway
extracellular matrix
mouse model
protein protein
small molecule
bone marrow
mesenchymal stem cells
binding protein