Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery.
Ricardo Blázquez-EncinasVíctor García-VioqueTeresa Caro-CuencaMaría Trinidad Moreno-MontillaFederica MangiliEmilia Alors-PérezSebastian VenturaAura D Herrera-MartínezPaula Moreno-CasadoMarco A CalzadoÁngel SalvatierraMaría A Gálvez-MorenoLynnette Fernandez-CuestaMatthieu FollRaúl M LuqueNicolas AlcalaSergio Pedraza-ArevaloAlejandro Ibáñez-CostaJusto P. CastañoPublished in: Journal of translational medicine (2023)
These results provide primary evidence for dysregulation of the splicing machinery in lung carcinoids and suggest a plausible functional role and therapeutic targetability of NOVA1, PRPF8 and SRSF10.
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