SWI/SNF remains localized to chromatin in the presence of SCHLAP1.

Jesse R RaabKeriayn N SmithCamarie C SpearCarl J MannerJ Mauro CalabreseTerry R Magnuson

Published in: Nature genetics (2018)

SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner.

Keyphrases

long noncoding rna
genome wide
gene expression
dna damage
transcription factor
single molecule