Treatment patterns and overall survival among patients with unresectable, stage III non-small-cell lung cancer.
Priyanka BobbiliKellie RyanMei S DuhAkanksha DuaAncilla W FernandesMelissa PavilackJorge E GomezPublished in: Future oncology (London, England) (2019)
Aim: To analyze treatment patterns and overall survival (OS) across time (2009-2014) among patients with unresected, stage III non-small-cell lung cancer (NSCLC). Patients & methods: Stage III NSCLC patients aged ≥65 years who initiated therapy were identified using SEER-Medicare data. Results: Among 4564 patients, 84% received chemotherapy (with or without radiotherapy), and 59% received chemoradiotherapy (CRT). Carboplatin + paclitaxel was the most frequent regimen. Median (interquartile range) OS among chemotherapy patients was 13.2 (6.0-28.9) months, and 14.8 (6.7-33.4) months among CRT patients. Among CRT patients, there was no difference in OS across years of CRT initiation. Conclusion: OS remained static across 2009-2014, indicating stagnancy in clinical outcomes for stage III NSCLC patients and a need for more effective therapeutic options.
Keyphrases
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- prognostic factors
- small cell lung cancer
- peritoneal dialysis
- healthcare
- clinical trial
- radiation therapy
- electronic health record
- rectal cancer
- deep learning
- epidermal growth factor receptor
- cell therapy
- tyrosine kinase
- radiation induced
- phase ii study