Login / Signup

Synthesis and Cytotoxicity of Monomethylated Betulinic Acid 3- O -α-l-Rhamnopyranosides.

Paul GormandAndré PichetteJean LegaultJérôme Alsarraf
Published in: ACS omega (2023)
Three original derivatives of the cytotoxic betulinic acid 3- O -α-l-rhamnopyranoside featuring a monomethylated rhamnoside residue were synthesized. An improved catalytic procedure was involved to functionalize the O -3 position of the monosaccharide in a site-selective fashion. The cytotoxicity of the novel compounds was evaluated in vitro to highlight the moderate impact of carbohydrate monomethylation on the biological activity of betulinic acid 3- O -α-l-rhamnopyranoside.
Keyphrases
  • minimally invasive
  • anti inflammatory