The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos.

Feifei LiDanyang WangRuigao SongChunwei CaoZhihua ZhangYu WangXiaoli LiJiaojiao HuangQiang LiuNaipeng HouBingxiang XuXiao LiXiaomeng GaoYan JiaJianguo ZhaoYanfang Wang

Published in: Genome biology (2020)

Our data highlight a potential unique 3D chromatin pattern of enriched superdomains in pig preimplantation embryos, an unusual decompartmentalization process during ZGA in the uniparental embryos, and an asynchronized TAD reprogramming between maternal and paternal genomes, implying a severe dysregulation of ZGA in the uniparental embryos in pigs.

Keyphrases

gene expression
dna damage
transcription factor
genome wide
electronic health record
dna methylation
oxidative stress
risk assessment
human health