A Single Dose of PEG-Asparaginase at the Beginning of Induction Not Only Accelerates MRD Clearance but Also Improves Long-Term Outcome in Children with B-Lineage ALL.
Alexander M PopovGünter HenzeJulia RoumiantsevaOleh BydanovMikhail BelevtsevTatiana VerzhbitskayaLiudmila MovchanGrigory A TsaurSvetlana LagoykoLiudmila ZharikovaNatalia MyakovaDmitry LitvinovOlga KhlebnikovaOlga StrenevaElena StolyarovaNatalia PonomarevaGalina NovichkovaLarisa FechinaOlga AleinikovaAlexander KarachunskiyPublished in: Cancers (2023)
Therefore, early use of PEG-ASP not only leads to an accelerated reduction of blasts, but also to an excellent outcome in a significantly larger proportion of patients in both risk groups.