Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation.

Shyng-Shiou F YuanLeong-Perng ChanHieu D H NguyenChang-Wei SuYuk-Kwan ChenJeff Yi-Fu ChenShigetaka ShimodairaStephen Chu-Sung HuSteven LoYen-Yun Wang

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our study provides novel mechanisms for areca nut-induced oral carcinogenesis, demonstrating that areca nut promotes M2 macrophage differentiation and secretion of oncogenic cytokines that critically activate malignant transformation of oral premalignant cells.

Keyphrases

high glucose
diabetic rats
induced apoptosis
drug induced
adipose tissue
cell cycle arrest
oxidative stress
transcription factor
cell proliferation
cell death
endoplasmic reticulum stress