Musculoskeletal pain and muscular weakness as the main symptoms of adult hypophosphatasia in a Spanish cohort: clinical characterization and identification of a new ALPL gene variant.
Pilar CalmarzaCarlos LaprestaMaría Martínez GarcíaJosé OchoaPaula Sienes BailoJavier Acha PérezJesús Beltrán AuderaEva Gonzalez-RocaPublished in: Journal of bone and mineral metabolism (2023)
Mild HPP patients presenting with diffuse symptoms such as musculoskeletal pain may be undiagnosed or misdiagnosed as osteoporosis patients by routine diagnosis. It is important to identify these individuals, to avoid inappropriate treatment with antiresorptive drugs.
Keyphrases
- chronic pain
- end stage renal disease
- pain management
- ejection fraction
- neuropathic pain
- newly diagnosed
- prognostic factors
- patient reported outcomes
- peritoneal dialysis
- replacement therapy
- postmenopausal women
- chronic kidney disease
- bone mineral density
- sleep quality
- clinical practice
- low grade
- young adults
- physical activity
- depressive symptoms
- resistance training
- postoperative pain
- body composition