Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study.
Sheng-Xin LiuMarica LeoneJonas F LudvigssonPaul LichtensteinBrian D'OnofrioAnn-Marie SvenssonSoffia GudbjörnsdottirSarah E BergenHenrik LarssonRalf Kuja-HalkolaAgnieszka ButwickaPublished in: Diabetes care (2022)
These results support existing evidence that children and adolescents with type 1 diabetes are at greater risks of developing depression, anxiety, and stress-related disorders and indicate that shared familial factors might contribute to these elevated risks. Our findings highlight the need for psychological consulting for children and their families in diabetes care. Quantitative and molecular genetic studies are warranted to further understand the etiology of these psychiatric disorders in type 1 diabetes.
Keyphrases
- sleep quality
- type diabetes
- depressive symptoms
- glycemic control
- human health
- early onset
- cardiovascular disease
- young adults
- insulin resistance
- physical activity
- high resolution
- risk assessment
- genome wide
- copy number
- adipose tissue
- heat stress
- early life
- gene expression
- single molecule
- skeletal muscle
- climate change
- childhood cancer