p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade.
David P MolkentineJessica M MolkentineKathleen A BridgesDavid R ValdecanasAnnika DhawanReshub BahriAndrew J HefnerManish KumarLiangpeng YangMohamed AbdelhakiemPhillip M PiferVlad SandulacheAakash ShethBeth M BeadleHoward D ThamesKathryn A MasonCurtis R PickeringRaymond E MeynHeath D SkinnerPublished in: Cancer research (2022)
In HPV-positive tumors, a previously undiscovered pathway directly links p16 to DNA damage repair and sensitivity to radiotherapy via a clinically relevant and pharmacologically targetable ubiquitin-mediated degradation pathway.