Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab.
Carmen Niño-TaravillaYazmín P Espinosa-VielmaHugo Otaola-ArcaMaria Cecilia PoliLorena I TapiaPaula Ortiz-FritzPublished in: Pediatric reports (2020)
We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment.
Keyphrases
- sars cov
- oxidative stress
- rheumatoid arthritis
- inflammatory response
- juvenile idiopathic arthritis
- case report
- rheumatoid arthritis patients
- newly diagnosed
- respiratory syndrome coronavirus
- end stage renal disease
- healthcare
- ejection fraction
- palliative care
- respiratory failure
- mental health
- clinical trial
- stem cells
- open label
- randomized controlled trial
- left ventricular
- young adults
- disease activity
- patient reported outcomes
- immune response
- study protocol
- pain management
- placebo controlled
- acute respiratory distress syndrome
- systemic lupus erythematosus
- patient reported
- combination therapy
- health insurance
- community acquired pneumonia
- mechanical ventilation