Metabolic adaptation characterizes short-term resistance to weight loss induced by a low-calorie diet in overweight/obese individuals.

Katie L WhytockKaren D CorbinStephanie A ParsonsAlok PachoriChristopher P BockKaren P JonesJoshua S SmithFanchao YiHui XieChristopher J PetucciStephen J GardellSteven R Smith

Published in: The American journal of clinical nutrition (2021)

Individuals who achieved predicted weight loss targets after a 28-d LCD were characterized by reduced metabolic adaptation. Accumulation of metabolites associated with acetyl-CoA excess and enhanced ketogenesis was identified in the ODS group.This trial was registered at clinicaltrials.gov as NCT01616082.

Keyphrases

weight loss
bariatric surgery
roux en y gastric bypass
gastric bypass
glycemic control
clinical trial
study protocol
ms ms
weight gain
obese patients
phase iii
adipose tissue