Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI-110) in Hepatocellular Carcinoma.

Minmin LiuLian ZhangHongtao LiToshinori HinoueWanding ZhouHitoshi OhtaniAnthony El-KhoueiryJohn DanielsCasey O'ConnellTanya Barauskas DorffQianjin LuDaniel J WeisenbergerGangning Liang

Published in: Hepatology (Baltimore, Md.) (2019)

Our integrative analysis has successfully linked the antitumor effects of SGI-110 to detailed epigenetic alterations in HCC cells, identified potential therapeutic targets, and provided a rationale for combination treatments of SGI-110 with immune checkpoint therapies.

Keyphrases

dna methylation
induced apoptosis
gene expression
cell cycle arrest
network analysis
circulating tumor
cell free
endoplasmic reticulum stress
oxidative stress
signaling pathway
risk assessment
climate change
data analysis