ELAC (3,12-di-O-acetyl-8-O-tigloilingol), a plant-derived lathyrane diterpene, induces subventricular zone neural progenitor cell proliferation through PKCβ activation.
Maribel Murillo-CarreteroNoelia Geribaldi-DoldánEugenia Flores-GiubiFrancisco García-BernalElkin A Navarro-QuirozManuel CarrascoAntonio J Macías-SánchezPilar Herrero-FoncubiertaAntonio Delgado-ArizaCristina VerásteguiJesús Domínguez-RiscartMourad DaoubiRosario Hernández-GalánCarmen CastroPublished in: British journal of pharmacology (2017)
We propose lathyranes like ELAC as new drug candidates to modulate adult neurogenesis through PKC activation. Functional and structural comparisons between ELAC and phorboids are included.