IL-10 polymorphisms +434T/C, +504G/T, and -2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population.

Sari RytkönenJarmo RitariJuha PeräsaariVille SaarelaMatti NuutinenTimo Jahnukainen

Published in: PloS one (2019)

A significant difference in the frequency of IL-10+434T and +504G alleles was found between TIN/TINU patients and control population. Genotype -2849TT was more frequently present in patients with TINU syndrome than in the reference subjects. Genetic variation in the inflammatory mediators may predispose to autoimmune nephritis and uveitis.

Keyphrases

end stage renal disease
juvenile idiopathic arthritis
ejection fraction
chronic kidney disease
ankylosing spondylitis
newly diagnosed
oxidative stress
case report
patient reported outcomes
drug induced