Blue mussel ( Mytilus edulis ) water extract ameliorates intestinal immune response in high-fat diet-streptozotocin-induced diabetic mice.
Sabri SudirmanYi-Yuh HwangChia-Hung SuTing-Yu LuHsiang-Ping KuoDeng-Fwu HwangZwe-Ling KongPublished in: Food & function (2024)
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels or hyperglycemia. Diabetes causes a decrease in immune function in the human body. Mytilus edulis has been identified as having anti-inflammatory properties and the ability to improve inflammation. Thus, this study aimed to investigate the function of Matsu M. edulis water extract (MWE) in mediating the regulation of immune responses and dysregulating the intestinal immune system in hyperglycemia mouse models. The mice were treated with MWE for seven weeks. The results showed that treatment with MWE has the ability to decrease triglyceride and total cholesterol concentrations. MWE also increases the interleukin (IL)-10 concentration and natural killer cell activation. It also improves the phagocytic capacity of monocytes in the colon and the proliferative capacity of lymphocytes in the mesentery. Furthermore, MWE also regulates the IL-6 concentration and the ratio of T helper 17 cells to regulatory T cells. Collectively, this extract can improve dyslipidemia, inflammatory responses, and dysregulation of the intestinal immune system. Therefore, M. edulis water extract can be used as an alternative treatment to reduce diabetes complications.
Keyphrases
- high fat diet
- oxidative stress
- regulatory t cells
- immune response
- diabetic rats
- anti inflammatory
- dendritic cells
- blood glucose
- glycemic control
- type diabetes
- induced apoptosis
- insulin resistance
- cardiovascular disease
- mouse model
- adipose tissue
- endothelial cells
- toll like receptor
- high glucose
- drug induced
- risk factors
- cell cycle arrest
- cell therapy
- mesenchymal stem cells
- high fat diet induced
- replacement therapy
- endoplasmic reticulum stress
- pi k akt
- smoking cessation