Login / Signup

Surface-bound matrix metalloproteinase-8 on macrophages: Contributions to macrophage pericellular proteolysis and migration through tissue barriers.

Xiaoyun WangDuo ZhangQuynh-Anh FucciClare M DolleryCaroline A Owen
Published in: Physiological reports (2021)
MMP-8 and TIMP-1 are expressed on the surface of activated human MDM and murine macrophages, but Mmp-8 is unlikely to bind to surface-bound Timp-1 on these cells. Surface-bound MMP-8 contributes to TIMP-resistant monocyte/macrophage pericellular proteolysis and macrophage migration through collagen-containing tissue barriers.
Keyphrases
  • endothelial cells
  • adipose tissue
  • induced apoptosis
  • cell migration
  • dendritic cells
  • oxidative stress
  • cell cycle arrest
  • cell proliferation
  • wound healing