Nuclear parameters and chromatin remodeling in epithelial cells and lymphocytes from the palpebral conjunctiva of dogs with keratoconjunctivitis sicca.

Daniela Moura Dos SantosMarcela Aldrovani RodriguesMarcella Rosa FilezioThais Guimarães Morato AbreuCamila Pinho Balthazar da SilveiraNathan Rocha das Neves CruzJosé Luiz Laus

Published in: Veterinary ophthalmology (2018)

Our results show that KCS promotes chromatin remodeling in epithelial cells and lymphocytes on the conjunctival surface of dogs. The changes described in this study are different from those reported for conjunctival cell nuclei of human KCS patients.

Keyphrases

end stage renal disease
dna damage
gene expression
transcription factor
endothelial cells
ejection fraction
peripheral blood
chronic kidney disease
newly diagnosed
genome wide
peritoneal dialysis
oxidative stress
patient reported outcomes
bone marrow
mesenchymal stem cells