Quantitative evaluation of brain iron accumulation in different stages of Parkinson's disease.

Kailyn R LiJosue Avecillas-ChasinThanh D NguyenKelly M GillenAlexey V DimovEileen ChangCarly SkudinBrian H KopellYi WangAlexander Shtilbans

Published in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2021)

Our data suggest iron accumulation occurs early in the disease course and only in the SN and RN of these patients. This is a large cross-sectional study of brain iron deposition in PD patients according to H&Y staging. Prospective studies are warranted to further validate QSM as a method to follow brain iron, which could serve as a disease biomarker and a therapeutic target.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
white matter
prognostic factors
resting state
peritoneal dialysis
multiple sclerosis
patient reported outcomes
cerebral ischemia
brain injury
deep learning