Old drug repositioning and new drug discovery through similarity learning from drug-target joint feature spaces.

Yi ZhengHui PengXiaocai ZhangZhixun ZhaoXiaoying GaoJinyan Li

Published in: BMC bioinformatics (2019)

Proper construction of highly-reliable negative samples can help the classification models learn a clear decision boundary which contributes to the performance improvement.

Keyphrases

drug discovery
machine learning
deep learning
adverse drug
decision making
high density