Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.

Arne HerringNirup K KurapatiSofia KrebsNils GrammonLuisa M ScholzGerrit VossMuhammad R MiahVanessa BudnyFabian MairingerKatharina HaaseSarah Teuber-HanselmannCelia DobersalskeSara SchrammKarl-Heinz JöckelYvonne MünsterKathy Keyvani

Published in: Neuropathology and applied neurobiology (2021)

These results reinforce the potential of KLK8 as a therapeutic target in AD.

Keyphrases

high fat diet induced
cancer therapy
genome wide
cognitive decline
copy number
human health
wild type
risk assessment
insulin resistance
gene expression