Multimodal analysis of the Preferred Retinal Location and the Transition Zone in patients with Stargardt Disease.
Tommaso VerdinaVivienne C GreensteinAndrea SodiStephen H TsangTomas R BurkeIlaria PasseriniRando AllikmetsGianni VirgiliGian Maria CavalliniStanislao RizzoPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2017)
In STGD1 eccentric PRLs are located away from the border of MA and associated with intact EZ bands and normal FAF. The TZ is characterized by structural and functional abnormalities. The results of multimodal imaging of the PRL and TZ suggest a possible sequence of retinal and functional changes with disease progression that may help in the planning of future therapies; RPE dysfunction appears to be the primary event leading to photoreceptor degeneration and then to RPE loss.