Midfacial toddler excoriation syndrome (MiTES): case series, diagnostic criteria and evidence for a pathogenic mechanism.
Nivedita SarveswaranYunisa PamelaAkhila A N ReddyAkash P MustariAnchala ParthasarathiAnthony J ManciniAnuradha BishnoiArun C InamadarBayanne OlabiFiona BrowneGargi N DeshmukhKenneth McWilliamKeshavamurthy VinaySahana SrinivasSamantha IbbsSivakumar NatarajanVadlamudi R RaoVijay ZawarVykuntaraju K GowdaSamiha S ShaikhCelia MossChristopher G WoodsIchrak DrissiPublished in: The British journal of dermatology (2024)
We provide diagnostic criteria for MiTES and improved longitudinal data. MiTES and CIP are distinct phenotypes, despite their genotypes varying by a single alanine in the PRDM12 polyalanine tract. We found clear distinctions between the cellular phenotypes of normal, MiTES and CIP cells. We hypothesize that the developmental environment of the trigeminal ganglion is unique and critically sensitive to pre- and postnatal levels of PRDM12.